Research Theme 2

      The Interaction Between Physical Activity, Appetite Regulation, Nutrition & Metabolic Health In Chronic Disease Settings

      Key theme aims

      1. To investigate the effects of different modes of exercise training protocols on appetite control in individuals with a high risk of and diagnosed chronic disease.
      2. To explore the role of exercise in preventing weight re-gain at key time-points in the post-bariatric surgery period.
      3. To improve and develop novel measurements of chronic low-grade inflammation.
      4. To elucidate the role of exercise and bicarbonate supplementation on severe renal disease.
      5. To carry out focused nutritional supplementation interventions investigating the impact of Vitamin D on glucose regulation and insulin sensitivity/resistance.

      Each aim will be addressed by an individual work package (WP) detailed below


        The Themes

        Theme 2 WP1

        Tightly controlled acute and chronic experimental training studies will be used to address the following questions Do obese men and women exhibit the same appetite energy intake and gut... Read more

        Theme 2 WP2

        Cohort development and an experimental randomised controlled trial will address the following questions What is the temporal pattern of physical activity and other lifestyle factors from the pre to... Read more

        Theme 2 WP3

        Laboratorybased experimental investigations and multidisciplinary device development teams will address the following questions To what extent do biopsies of subcutaneous adipose tissue reflect... Read more

        Theme 2 WP4

        A 2x2 factorial trial will address the following questions Can resistance training overcome the negative effects of acidosis and elicit an increase in muscle mass in predialysis CKD patientsDoes the... Read more

        Theme 2 WP5

        Placebo controlled experimental trials will address the following questions Can Vitamin D supplementation improve insulin sensitivity and improve glucose regulation compared to placeboDoes a... Read more